Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.80 |
| ▸ | RAF1 | P04049 | 5/20 | 0.80 |
| ▸ | SRC | P12931 | 5/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.57 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 6/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545615 | 0.95 | BRAF (0.81) | BRAFRAF1SRCMAPK14MAP3K20 | |
| SCHEMBL10200309 | 0.93 | BRAF (0.78) | BRAFRAF1SRCMAPK14MAP3K20 | |
| SCHEMBL545427 | 0.89 | RAF1 (1.00) | BRAFRAF1SRCMAPK14MAP3K20 | |
| SCHEMBL546225 | 0.88 | BRAF (0.62) | BRAFRAF1SRCABL1NTRK1 | |
| SCHEMBL5430584 | 0.88 | RAF1 (0.85) | BRAFRAF1SRCMAPK14MAP3K20 | |
| SCHEMBL545691 | 0.86 | BRAF (0.80) | BRAFRAF1SRCMAPK14KDR | |
| SCHEMBL545253 | 0.85 | BRAF (0.58) | BRAFRAF1SRCABL1NTRK1 | |
| SCHEMBL546346 | 0.85 | RAF1 (1.00) | BRAFRAF1SRCMAPK14MAP3K20 | |
| SCHEMBL19911112 | 0.85 | SRC (1.00) | BRAFRAF1SRCMAPK14MAP3K20 | |
| SCHEMBL545580 | 0.83 | BRAF (0.63) | BRAFRAF1SRCABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
| WO-2007067444-A1 | BICYCLIC COMPOUNDS WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MAP3K20, MAP3K1, MAP3K5 | BRAF 215/4885RAF1 198/4885SRC 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.