Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.76 |
| ▸ | RAF1 | P04049 | 13/20 | 0.76 |
| ▸ | KDR | P35968 | 7/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545001 | 0.95 | BRAF (0.75) | BRAFRAF1KDR | |
| SCHEMBL545980 | 0.94 | BRAF (0.77) | BRAFRAF1KDR | |
| SCHEMBL545371 | 0.92 | BRAF (0.80) | BRAFRAF1KDR | |
| SCHEMBL545925 | 0.92 | BRAF (0.80) | BRAFRAF1KDR | |
| SCHEMBL545213 | 0.92 | BRAF (0.80) | BRAFRAF1KDR | |
| SCHEMBL545664 | 0.91 | BRAF (0.79) | BRAFRAF1KDR | |
| SCHEMBL546107 | 0.91 | BRAF (0.79) | BRAFRAF1KDR | |
| SCHEMBL5428337 | 0.91 | BRAF (0.78) | BRAFRAF1KDR | |
| SCHEMBL545579 | 0.90 | BRAF (0.77) | BRAFRAF1KDR | |
| SCHEMBL545947 | 0.90 | BRAF (0.77) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |