Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 12/20 | 0.49 |
| ▸ | RAF1 | P04049 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546283 | 0.88 | BRAF (0.48) | BRAFRAF1KDRHRH3EGFR | |
| SCHEMBL545647 | 0.88 | BRAF (0.51) | ADRB3BRAFRAF1KDREGFR | |
| SCHEMBL546051 | 0.88 | BRAF (0.50) | ADRB3BRAFRAF1KDREGFR | |
| SCHEMBL545864 | 0.88 | NPC1 (0.53) | ADRB3BRAFRAF1KDRHDAC8 | |
| SCHEMBL546140 | 0.88 | BRAF (0.50) | ADRB3BRAFRAF1KDRHDAC8 | |
| SCHEMBL545353 | 0.88 | BRAF (0.49) | BRAFRAF1KDRHRH3EGFR | |
| SCHEMBL545415 | 0.88 | BRAF (0.54) | BRAFRAF1KDRHDAC8NFKB1 | |
| SCHEMBL545254 | 0.87 | BRAF (0.49) | ADRB3BRAFRAF1KDREGFR | |
| SCHEMBL546430 | 0.87 | BRAF (0.52) | ADRB3BRAFRAF1KDRHDAC8 | |
| SCHEMBL545993 | 0.87 | BRAF (0.51) | ADRB3BRAFRAF1KDRHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MAP3K20, MAP3K1, MAP3K5 | ADRB3 2231/4885BRAF 215/4885RAF1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.