Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.58 |
| ▸ | RAF1 | P04049 | 7/20 | 0.58 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545366 | 0.93 | BRAF (0.67) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL546730 | 0.93 | BRAF (0.65) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL545758 | 0.87 | BRAF (0.64) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL546015 | 0.87 | BRAF (0.64) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL546043 | 0.86 | BRAF (0.63) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL546358 | 0.86 | BRAF (0.56) | BRAFRAF1LCKKDRFYN | |
| SCHEMBL546265 | 0.85 | BRAF (0.68) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL545511 | 0.85 | BRAF (0.74) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL545770 | 0.83 | BRAF (0.60) | BRAFRAF1LCKKDRMAPK14 | |
| SCHEMBL5417941 | 0.82 | BRAF (0.61) | BRAFRAF1LCKKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |