Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | BRAF | P15056 | 10/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.55 |
| ▸ | RAF1 | P04049 | 7/20 | 0.53 |
| ▸ | ARAF | P10398 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | MUSK | O15146 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546771 | 0.92 | BRAF (0.57) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL545174 | 0.90 | RAF1 (0.58) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL545949 | 0.90 | KDR (0.74) | KDRBRAF | |
| SCHEMBL10200762 | 0.89 | KDR (0.54) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL5435203 | 0.88 | HDAC1 (0.56) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL545312 | 0.88 | KDR (0.55) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL545646 | 0.87 | RAF1 (0.56) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL5424081 | 0.87 | KDR (0.60) | KDRBRAF | |
| Hydrochloric Acid SCHEMBL545435 | 0.86 | RAF1 (0.55) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL14493429 | 0.86 | BRAF (0.53) | KDRBRAFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MAP3K20, MAP3K1, MAP3K5 | KDR 1264/4885BRAF 215/4885HDAC3 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.