Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.80 |
| ▸ | RAF1 | P04049 | 10/20 | 0.80 |
| ▸ | KDR | P35968 | 10/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545832 | 0.92 | BRAF (0.78) | BRAFRAF1KDR | |
| SCHEMBL545455 | 0.92 | BRAF (0.82) | BRAFRAF1KDR | |
| SCHEMBL545226 | 0.91 | BRAF (0.84) | BRAFRAF1KDR | |
| SCHEMBL545016 | 0.91 | BRAF (0.87) | BRAFRAF1KDR | |
| SCHEMBL545760 | 0.90 | BRAF (0.85) | BRAFRAF1KDR | |
| SCHEMBL5429919 | 0.90 | BRAF (0.82) | BRAFRAF1KDR | |
| SCHEMBL545032 | 0.89 | BRAF (1.00) | BRAFRAF1KDR | |
| SCHEMBL545837 | 0.89 | BRAF (1.00) | BRAFRAF1KDR | |
| SCHEMBL546550 | 0.89 | BRAF (1.00) | BRAFRAF1KDR | |
| SCHEMBL546657 | 0.89 | BRAF (0.81) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |