Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.80 |
| ▸ | RAF1 | P04049 | 15/20 | 0.80 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ROS1 | P08922 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546657 | 0.93 | BRAF (0.81) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL545729 | 0.90 | BRAF (0.86) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL545807 | 0.89 | BRAF (0.75) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL546019 | 0.89 | BRAF (1.00) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL545438 | 0.89 | BRAF (1.00) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL545490 | 0.89 | BRAF (1.00) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL545505 | 0.88 | BRAF (0.84) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL10200925 | 0.88 | BRAF (0.82) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL544442 | 0.88 | BRAF (0.89) | BRAFRAF1KDRPLK4AURKA | |
| SCHEMBL546908 | 0.86 | BRAF (0.80) | BRAFRAF1KDRPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |