Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 16/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 15/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.37 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407649 | 0.87 | NR1H2 (0.70) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1408353 | 0.85 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407612 | 0.85 | NR1H3 (0.61) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407505 | 0.84 | NR1H2 (0.64) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407860 | 0.83 | NR1H2 (0.75) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407733 | 0.83 | NR1H2 (0.58) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407865 | 0.82 | NR1H2 (0.63) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1408275 | 0.81 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL5954640 | 0.81 | NR1H2 (0.76) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407211 | 0.81 | NR1H2 (0.90) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773781-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006017384-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | WYETH (US) | 2006-02-16 | — | — | WO | disclosed |