⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935050 | 0.53 | — | — | |
| SCHEMBL3064113 | 0.45 | — | — | |
| SCHEMBL380648 | 0.36 | — | — | |
| SCHEMBL18032665 | 0.35 | — | — | |
| SCHEMBL9248 | 0.35 | — | — | |
| SCHEMBL1772709 | 0.31 | — | — | |
| SCHEMBL14225435 | 0.29 | — | — | |
| SCHEMBL34570 | 0.27 | — | — | |
| SCHEMBL1203 | 0.27 | — | — | |
| SCHEMBL25204735 | 0.25 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226924-B2 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2007-06-05 | — | — | US | disclosed |
| US-7226924-B2 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2007-06-05 | — | — | US | disclosed |
| US-7226924-B2 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2007-06-05 | — | — | US | disclosed |
| CN-1243753-C | Substituted 3, 4-dihydro-pyrimido [1, 2-a ] pyrimidines and 3, 4-dihydro-pyrazino [1, 2-a ] pyrimidines | GRUENENTHAL GMBH (DE) | 2006-03-01 | — | — | CN | disclosed |
| EP-1325010-B1 | SUBSTITUTED 3.4-DIHYDRO-PYRIMIDO [1,2-A]PYRIMIDINES AND 3.4-DIHYDROPYRAZINO [1,2-A]PYRIMIDINES | GRUENENTHAL GMBH (DE) | 2005-04-27 | — | — | EP | disclosed |
| EP-1325010-B1 | SUBSTITUTED 3.4-DIHYDRO-PYRIMIDO [1,2-A]PYRIMIDINES AND 3.4-DIHYDROPYRAZINO [1,2-A]PYRIMIDINES | GRUENENTHAL GMBH (DE) | 2005-04-27 | — | — | EP | disclosed |
| CN-1469879-A | Substituted 3,4-dihydro-pyrimido[1,2-A] pyrimidines and 3,4-dihydropyrazino [1,2-A] pyrimidines | — | 2004-01-21 | — | — | CN | disclosed |
| US-20030220322-A1 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2003-11-27 | — | — | US | disclosed |
| US-20030220322-A1 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2003-11-27 | — | — | US | disclosed |
| US-20030220322-A1 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use | GRUENENTHAL GMBH (DE) | 2003-11-27 | — | — | US | disclosed |
| EP-1325010-A1 | SUBSTITUTED 3.4-DIHYDRO-PYRIMIDO 1,2-A]PYRIMIDINES AND 3.4-DIHYDROPYRAZINO 1,2-A]PYRIMIDINES | Grünenthal GmbH (DE) | 2003-07-09 | — | — | EP | disclosed |
| EP-1325010-A1 | SUBSTITUTED 3.4-DIHYDRO-PYRIMIDO 1,2-A]PYRIMIDINES AND 3.4-DIHYDROPYRAZINO 1,2-A]PYRIMIDINES | Grünenthal GmbH (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030934-A1 | SUBSTITUTED 3.4-DIHYDRO-PYRIMIDO[1,2-A]PYRIMIDINES AND 3.4-DIHYDROPYRAZINO[1,2-A]PYRIMIDINES | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002030934-A1 | SUBSTITUTED 3.4-DIHYDRO-PYRIMIDO[1,2-A]PYRIMIDINES AND 3.4-DIHYDROPYRAZINO[1,2-A]PYRIMIDINES | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | disclosed |