Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.70 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5476319 | 1.00 | CHEK1 (0.70) | CHEK1PIM1PIM2 | |
| SCHEMBL5473196 | 1.00 | CHEK1 (0.70) | CHEK1PIM1PIM2 | |
| SCHEMBL5473341 | 0.90 | CHEK1 (0.65) | CHEK1 | |
| SCHEMBL5475575 | 0.90 | CHEK1 (0.65) | CHEK1 | |
| SCHEMBL5465447 | 0.87 | CHEK1 (0.61) | CHEK1 | |
| SCHEMBL5478991 | 0.85 | CHEK1 (0.70) | CHEK1 | |
| SCHEMBL5470113 | 0.85 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL5472361 | 0.85 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL5470243 | 0.84 | CHEK1 (0.65) | CHEK1 | |
| SCHEMBL5465078 | 0.84 | CHEK1 (0.69) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | claimed |
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | TP53, BRCA1, KLK3 | CHEK1 13/4885PIM1 1275/4885PIM2 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.