Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 17/20 | 0.73 |
| ▸ | AKT1 | P31749 | 13/20 | 0.73 |
| ▸ | AKT2 | P31751 | 13/20 | 0.73 |
| ▸ | AKT3 | Q9Y243 | 12/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.72 |
| ▸ | RPS6KA1 | Q15418 | 7/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.58 |
| ▸ | GSK3A | P49840 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.58 |
| ▸ | MARK3 | P27448 | 2/20 | 0.58 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | PRKX | P51817 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763216 | 1.00 | RPS6KA5 (0.73) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| SCHEMBL4808747 | 0.88 | RPS6KA5 (0.69) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| SCHEMBL4714616 | 0.88 | RPS6KA5 (0.69) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| SCHEMBL14252574 | 0.87 | RPS6KA5 (0.91) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| Hydrochloric Acid SCHEMBL4715800 | 0.86 | RPS6KA5 (0.89) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| Hydrochloric Acid SCHEMBL6645116 | 0.86 | RPS6KA5 (0.89) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| Hydrochloric Acid SCHEMBL4716741 | 0.86 | RPS6KA5 (0.89) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| SCHEMBL5462306 | 0.85 | RPS6KA5 (0.65) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| Hydrochloric Acid SCHEMBL4716474 | 0.84 | RPS6KA5 (0.98) | RPS6KA5AKT1AKT2AKT3ROCK1 | |
| SCHEMBL4762205 | 0.84 | RPS6KA5 (0.65) | RPS6KA5AKT1AKT2AKT3ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123561-A1 | Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors | LEE DENNIS | 2007-05-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123561-A1 | Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors | TNK2, CDC42BPB, CDC42BPA | RPS6KA5 117/4885AKT1 29/4885AKT2 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.