Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.69 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453787 | 0.90 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5758540 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL5465541 | 0.85 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL5637675 | 0.82 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL155120 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL29413256 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3101476 | 0.81 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL5638136 | 0.81 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL5638122 | 0.81 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Elbimilast SCHEMBL1865431 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG | 2007-04-26 | — | — | US | claimed |
| EP-1562584-A1 | NOVEL HYDROXYINDOLES, USE AS INHIBITORS OF PHOSPHODIESTERASE 4 AND METHOD FOR PRODUCTION THEREOF | Elbion AG (DE) | 2005-08-17 | — | — | EP | claimed |
| US-20040147759-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG (DE) | 2004-07-29 | — | — | US | claimed |
| WO-2004045607-A1 | NOVEL HYDROXYINDOLES, USE AS INHIBITORS OF PHOSPHODIESTERASE 4 AND METHOD FOR PRODUCTION THEREOF | ELBION AG (DE) | 2004-06-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147759-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | PDE4B, PDE4A, PDE4D | PDE4A 2/4885PDE4B 1/4885PDE4C 4/4885 |
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | PDE4B, PDE4A, PDE4D | PDE4A 2/4885PDE4B 1/4885PDE4C 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.