SCHEMBL5475403

SCHEMBL5475403

CCOC(=O)C(C)(C)Oc1c(C)cc(CN(CC(=O)NC)Cc2nc(-c3ccc(Cl)cc3)oc2C)cc1C

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 13/20 0.52
PPARG P37231 12/20 0.52
HSD17B10 Q99714 2/20 0.43
MAPT P10636 3/20 0.42
TP53 P04637 1/20 0.42
TARBP2 Q15633 1/20 0.41
TSHR P16473 2/20 0.39
POLB P06746 1/20 0.39
ALDH1A1 P00352 1/20 0.39
ABCB11 O95342 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
HTR2A P28223 1/20 0.38
PMP22 Q01453 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5670292 0.94 PPARG (0.53) PPARAPPARGMAPTTP53TARBP2
SCHEMBL5483150 0.92 PPARA (0.61) PPARAPPARG
SCHEMBL5482151 0.92 PPARG (0.52) PPARAPPARGMAPTTP53TSHR
SCHEMBL5482143 0.91 PPARG (0.56) PPARAPPARGHSD17B10
SCHEMBL5487241 0.91 PPARA (0.62) PPARAPPARG
SCHEMBL5670459 0.89 PPARA (0.52) PPARAPPARGHSD17B10MAPTTP53
SCHEMBL5476483 0.85 PPARA (0.53) PPARAPPARGHSD17B10MAPTTP53
SCHEMBL14414919 0.85 PPARA (0.60) PPARAPPARG
SCHEMBL5668536 0.85 PPARA (0.60) PPARAPPARG
SCHEMBL5480373 0.85 PPARG (0.57) PPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD PPARA 1/4885PPARG 2/4885HSD17B10 950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.