Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 11/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CIT | O14578 | 1/20 | 0.32 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477093 | 1.00 | PTGDR2 (0.36) | PTGDR2AURKAAURKBADAMTS4AR | |
| SCHEMBL5477159 | 0.90 | AURKA (0.40) | PTGDR2AURKAAURKBARPLK4 | |
| SCHEMBL5477155 | 0.90 | AURKA (0.40) | PTGDR2AURKAAURKBARPLK4 | |
| SCHEMBL4312403 | 0.87 | PTGDR2 (0.38) | PTGDR2AURKAAURKBARMEN1 | |
| SCHEMBL4316715 | 0.87 | AURKA (0.41) | PTGDR2AURKAAURKBMEN1LMNA | |
| SCHEMBL4312400 | 0.85 | PTGDR2 (0.37) | PTGDR2AURKAAURKBARMEN1 | |
| SCHEMBL4312396 | 0.85 | PTGDR2 (0.37) | PTGDR2AURKAAURKBARMEN1 | |
| SCHEMBL5477095 | 0.85 | PTGDR2 (0.37) | PTGDR2AURKAAURKBARMEN1 | |
| SCHEMBL5477089 | 0.84 | AURKA (0.35) | PTGDR2AURKAAURKBARMEN1 | |
| SCHEMBL4316683 | 0.81 | AURKA (0.40) | PTGDR2AURKAAURKBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282588-B2 | Azaindole inhibitors of aurora kinases | SMITHKLINE BEECHAM (US) | 2007-10-16 | — | — | US | disclosed |
| US-20070149561-A1 | AZAINDOLE INHIBITORS OF AURORA KINASES | GLAXOSMITHKLINE LLC | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149561-A1 | AZAINDOLE INHIBITORS OF AURORA KINASES | AURKA, AURKC, AURKB | PTGDR2 4533/4885AURKA 1/4885AURKB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.