Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.76 |
| ▸ | CDK2 | P24941 | 6/20 | 0.76 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.74 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.56 |
| ▸ | TUBB | P07437 | 1/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477365 | 1.00 | CCNE1 (0.76) | CCNE1CDK2CCNE2MDM2EGFR | |
| SCHEMBL6966253 | 0.85 | CDK2 (0.76) | CCNE1CDK2CCNE2RETPDGFRB | |
| SCHEMBL6966246 | 0.85 | CDK2 (0.76) | CCNE1CDK2CCNE2RETPDGFRB | |
| SCHEMBL6001660 | 0.84 | PDPK1 (0.73) | CCNE1CDK2CCNE2EGFRERBB2 | |
| SCHEMBL6001654 | 0.84 | PDPK1 (0.73) | CCNE1CDK2CCNE2EGFRERBB2 | |
| SCHEMBL5470701 | 0.83 | CCNE1 (1.00) | CCNE1CDK2CCNE2MDM2ERBB2 | |
| SCHEMBL5470703 | 0.83 | CCNE1 (1.00) | CCNE1CDK2CCNE2MDM2ERBB2 | |
| SCHEMBL6957516 | 0.82 | CCNE1 (0.71) | CCNE1CDK2CCNE2RET | |
| SCHEMBL6957524 | 0.82 | CCNE1 (0.71) | CCNE1CDK2CCNE2RET | |
| SCHEMBL6963391 | 0.80 | CCNE1 (0.67) | CCNE1CDK2CCNE2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | claimed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | claimed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | CCNE1 2353/4885CDK2 769/4885CCNE2 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.