Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.60 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477376 | 1.00 | NPC1 (0.80) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL5469692 | 0.89 | NPC1 (1.00) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL5469690 | 0.89 | NPC1 (1.00) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL16442345 | 0.89 | NPC1 (1.00) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL29367529 | 0.89 | NPC1 (1.00) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL13343864 | 0.88 | NPC1 (0.61) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL3568956 | 0.88 | NPC1 (0.61) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL13343860 | 0.88 | NPC1 (0.61) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL5472383 | 0.86 | NPC1 (0.78) | NPC1MDM2CCNE1CDK2CSNK1D | |
| SCHEMBL5472385 | 0.86 | NPC1 (0.78) | NPC1MDM2CCNE1CDK2CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | NPC1 4188/4885MDM2 4274/4885CCNE1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.