Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | SIK1 | P57059 | 3/20 | 0.36 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.36 |
| ▸ | SIK3 | Q9Y2K2 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479033 | 1.00 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL5479681 | 1.00 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL5477321 | 0.94 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL5473831 | 0.88 | PDE4D (0.54) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL5480706 | 0.86 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4CFYN | |
| SCHEMBL5478618 | 0.85 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL5476150 | 0.84 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CROCK2 | |
| SCHEMBL5477971 | 0.84 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5476753 | 0.84 | CD274 (0.50) | PDE4DPDE4BPDE4APDE4CSIK1 | |
| SCHEMBL5473560 | 0.82 | CYP2D6 (0.50) | PDE4DPDE4BPDE4APDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | claimed |
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
| EP-1725534-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005087745-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | PDE4A, PDE4B, PDE4C | PDE4D 4/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.