Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 9/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039904 | 0.87 | HDAC1 (0.58) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL6387936 | 0.87 | HDAC1 (0.57) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL17045851 | 0.86 | HDAC1 (0.61) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL28539271 | 0.81 | CYP2C19 (0.68) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL7043051 | 0.80 | HDAC2 (0.90) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL6386218 | 0.79 | GAA (0.70) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL15668427 | 0.78 | HDAC1 (0.72) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL7045815 | 0.78 | HDAC2 (1.00) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL12889789 | 0.77 | HDAC1 (1.00) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL3381300 | 0.76 | HDAC1 (0.70) | HDAC2HDAC1HDAC6HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | disclosed |