SCHEMBL5480720

SCHEMBL5480720

CCOC(=O)C(C)(C)Oc1c(C)cc(CN(CC(=O)N(C)C2CC2)Cc2nc(-c3ccccc3)oc2C)cc1C

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 0.58
PPARA Q07869 18/20 0.58
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HSP90AA1 P07900 1/20 0.40
MAPK1 P28482 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
PDE10A Q9Y233 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5485464 0.93 PPARA (0.67) PPARGPPARA
SCHEMBL5478826 0.91 PPARG (0.63) PPARGPPARA
SCHEMBL5487772 0.89 PPARG (0.65) PPARGPPARA
SCHEMBL5485664 0.89 PPARA (0.71) PPARGPPARA
SCHEMBL5480728 0.88 PPARA (0.57) PPARGPPARAMEN1ALDH1A1HSP90AA1
SCHEMBL5472989 0.87 PPARG (0.63) PPARGPPARA
SCHEMBL5485484 0.87 PPARA (0.57) PPARGPPARAMEN1ALDH1A1HSP90AA1
SCHEMBL5476130 0.86 PPARG (0.60) PPARGPPARA
SCHEMBL5473447 0.86 PPARG (0.61) PPARGPPARA
SCHEMBL5483150 0.86 PPARA (0.61) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885MEN1 4790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.