Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 6/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473283 | 0.95 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL5056407 | 0.90 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL5479644 | 0.89 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL5476149 | 0.87 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL5480188 | 0.87 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CTLR9 | |
| SCHEMBL5056730 | 0.86 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL5481979 | 0.85 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL5479675 | 0.84 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL5477909 | 0.84 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL5479779 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | claimed |
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
| EP-1725534-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005087745-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | PDE4A, PDE4B, PDE4C | PDE4D 4/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.