Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | PLK4 | O00444 | 2/20 | 0.68 |
| ▸ | PLK1 | P53350 | 2/20 | 0.68 |
| ▸ | FLT3 | P36888 | 6/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 4/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 2/20 | 0.57 |
| ▸ | LTK | P29376 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.57 |
| ▸ | CDK7 | P50613 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481832 | 1.00 | NPC1 (0.68) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL5472209 | 0.85 | FLT3 (0.59) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL5472619 | 0.85 | LRRK2 (0.58) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL14448885 | 0.85 | LRRK2 (0.58) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL14448904 | 0.85 | FLT3 (0.59) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL5472208 | 0.85 | FLT3 (0.59) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL5469641 | 0.85 | LRRK2 (0.70) | RETPDGFRBRPS6KA3LRRK2 | |
| SCHEMBL5472614 | 0.85 | LRRK2 (0.58) | NPC1PLK4PLK1FLT3MAP3K7 | |
| SCHEMBL5469637 | 0.85 | LRRK2 (0.70) | RETPDGFRBRPS6KA3LRRK2 | |
| SCHEMBL5470660 | 0.84 | CDK7 (0.62) | NPC1PLK4PLK1FLT3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | claimed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | claimed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | NPC1 4188/4885PLK4 3502/4885PLK1 1202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.