Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.85 |
| ▸ | EGFR | P00533 | 9/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5699185 | 0.94 | ERBB2 (0.87) | ERBB2EGFRKCNH2 | |
| SCHEMBL4468699 | 0.94 | ERBB2 (0.87) | ERBB2EGFRKCNH2 | |
| SCHEMBL4471157 | 0.94 | ERBB2 (0.87) | ERBB2EGFRKCNH2 | |
| SCHEMBL4481460 | 0.92 | ERBB2 (0.84) | ERBB2EGFRKCNH2 | |
| SCHEMBL4473717 | 0.92 | ERBB2 (0.84) | ERBB2EGFRKCNH2 | |
| SCHEMBL4470280 | 0.92 | ERBB2 (1.00) | ERBB2EGFRKCNH2 | |
| SCHEMBL4476802 | 0.92 | ERBB2 (1.00) | ERBB2EGFRKCNH2 | |
| SCHEMBL4485153 | 0.91 | ERBB2 (0.88) | ERBB2EGFRKCNH2 | |
| SCHEMBL4471016 | 0.91 | ERBB2 (0.78) | ERBB2EGFRKCNH2 | |
| SCHEMBL4472938 | 0.91 | ERBB2 (0.86) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511491-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | disclosed |