Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.56 |
| ▸ | STK3 | Q13188 | 6/20 | 0.51 |
| ▸ | STK4 | Q13043 | 5/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | STK25 | O00506 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180838 | 0.90 | EGFR (0.52) | EGFRSTK4PRKCQERBB2 | |
| SCHEMBL4190265 | 0.80 | EGFR (0.52) | EGFRPRKCQERBB2 | |
| SCHEMBL4192096 | 0.76 | EGFR (0.55) | EGFRPRKCQERBB2 | |
| SCHEMBL28622133 | 0.74 | STK3 (0.77) | EGFRSTK3STK4ERBB2SRC | |
| SCHEMBL2983759 | 0.73 | PRKCQ (0.61) | PRKCQLYN | |
| SCHEMBL30218362 | 0.72 | MAPT (0.58) | EGFRERBB2ERBB3SYKERBB4 | |
| SCHEMBL215759 | 0.72 | MAPT (0.58) | EGFRERBB2ERBB3SYKERBB4 | |
| SCHEMBL29780767 | 0.72 | MAPT (0.58) | EGFRERBB2ERBB3SYKERBB4 | |
| SCHEMBL4191889 | 0.72 | EGFR (0.57) | EGFRPRKCQERBB2 | |
| SCHEMBL5469863 | 0.71 | PRKCQ (0.69) | EGFRPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | WYETH | 2007-12-13 | — | — | US | claimed |
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | WYETH | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K6 | EGFR 2704/4885STK3 139/4885STK4 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.