Torcetrapib

SCHEMBL5482162

[2H]C([2H])([2H])OC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CC(C([2H])([2H])C([2H])([2H])[2H])N(C(=O)OC([2H])([2H])C([2H])([2H])[2H])c2ccc(C(F)(F)F)cc21

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CETP

The experimentally established mechanism targets of Torcetrapib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	CETP known ✓	P11597	20/20	0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Torcetrapib SCHEMBL3196214	1.00	CETP (0.69)	CETP
Torcetrapib SCHEMBL3188502	0.96	CETP (0.75)	CETP
Torcetrapib SCHEMBL3203544	0.96	CETP (0.75)	CETP
Torcetrapib SCHEMBL3203552	0.96	CETP (0.75)	CETP
Torcetrapib SCHEMBL3186323	0.94	CETP (0.74)	CETP
Torcetrapib SCHEMBL3186334	0.94	CETP (0.74)	CETP
Torcetrapib SCHEMBL3197818	0.91	CETP (0.79)	CETP
Torcetrapib SCHEMBL3204358	0.91	CETP (0.79)	CETP
Torcetrapib SCHEMBL3197811	0.91	CETP (0.79)	CETP
Torcetrapib SCHEMBL3198472	0.90	CETP (0.86)	CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2007120621-A2	NONEL 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES	CONCERT PHARMACEUTICALS, INC. (US)	2007-10-25	—	—	WO	disclosed