Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 20/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | TEK | Q02763 | 3/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5488568 | 0.85 | EPHB4 (0.83) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5479028 | 0.77 | EPHB4 (0.86) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5479180 | 0.77 | EPHB4 (0.87) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5479560 | 0.76 | EPHB4 (0.84) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5486249 | 0.76 | EPHB4 (1.00) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5482749 | 0.76 | EPHB4 (0.84) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5478611 | 0.76 | EPHB4 (0.82) | EPHB4KDRTEK | |
| SCHEMBL5482742 | 0.76 | EPHB4 (0.83) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5483673 | 0.75 | EPHB4 (0.88) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL6532158 | 0.74 | EPHB4 (0.75) | EPHB4KDRTEKABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259164-B2 | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2007-08-21 | — | — | US | disclosed |