Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.45 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428720 | 0.92 | TYK2 (0.49) | PIK3CAPIK3CGPIK3CBTYK2SYK | |
| SCHEMBL426412 | 0.90 | PIK3CA (0.45) | PIK3CAPIK3CGMTORPIK3CBTYK2 | |
| SCHEMBL431043 | 0.88 | TYK2 (0.48) | PIK3CAPIK3CGPIK3CBTYK2SYK | |
| SCHEMBL427044 | 0.88 | PIK3CA (0.44) | PIK3CAPIK3CGMTORPIK3CBTYK2 | |
| SCHEMBL427231 | 0.87 | NPC1 (0.44) | PIK3CAPIK3CGMTORPIK3CBTYK2 | |
| SCHEMBL425757 | 0.87 | PIK3CA (0.46) | PIK3CAPIK3CGPIK3CBTYK2SYK | |
| SCHEMBL430156 | 0.86 | PIK3CA (0.44) | PIK3CAPIK3CGMTORPIK3CBTYK2 | |
| SCHEMBL429416 | 0.85 | TYK2 (0.48) | PIK3CAPIK3CGPIK3CBTYK2SYK | |
| SCHEMBL427852 | 0.85 | MAPT (0.54) | PIK3CATYK2SYKIRAK4KDM4E | |
| SCHEMBL425546 | 0.85 | PIK3CA (0.41) | PIK3CAPIK3CGMTORPIK3CBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |