Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1732445 | 0.99 | F2R (0.43) | F2R | |
| Bromide SCHEMBL1732336 | 0.88 | F2R (0.43) | F2RKDM4ENPC1MAPTRAB9A | |
| SCHEMBL1731824 | 0.87 | F2R (0.40) | F2R | |
| Bromide SCHEMBL1731024 | 0.86 | F2R (0.41) | F2R | |
| Bromide SCHEMBL1729005 | 0.85 | F2R (0.48) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1729515 | 0.85 | F2R (0.45) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1730908 | 0.84 | F2R (0.42) | F2RKDM4ENPC1MAPTRAB9A | |
| SCHEMBL6544708 | 0.84 | F2R (0.47) | F2RKDM4ENPC1MAPTRAB9A | |
| SCHEMBL6545016 | 0.82 | F2R (0.44) | F2R | |
| Bromide SCHEMBL6543938 | 0.82 | F2R (0.37) | F2RKDM4ENPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135427-A1 | 1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |