Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478464 | 0.88 | EPHB4 (0.78) | EPHB4 | |
| SCHEMBL5474653 | 0.87 | EPHB4 (0.74) | EPHB4 | |
| SCHEMBL5486691 | 0.87 | EPHB4 (1.00) | EPHB4 | |
| SCHEMBL6529106 | 0.86 | EPHB4 (0.73) | EPHB4 | |
| SCHEMBL5486083 | 0.85 | EPHB4 (0.78) | EPHB4 | |
| SCHEMBL5478632 | 0.85 | EPHB4 (1.00) | EPHB4 | |
| SCHEMBL5478475 | 0.85 | EPHB4 (0.83) | EPHB4 | |
| SCHEMBL5474526 | 0.84 | EPHB4 (0.85) | EPHB4 | |
| SCHEMBL5475219 | 0.80 | EPHB4 (0.79) | EPHB4 | |
| SCHEMBL5485684 | 0.80 | EPHB4 (0.81) | EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259164-B2 | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity | CGI PHARMACEUTICALS, INC. (US) | 2007-08-21 | — | — | US | disclosed |
| WO-2005019220-A9 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS MODULATORS OF KINASE ACTIVITY | CELLULAR GENOMICS INC (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20050085484-A1 | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity | GILEAD CONNECTICUT, INC. | 2005-04-21 | — | — | US | disclosed |
| WO-2005019220-A2 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS MODULATORS OF KINASE ACTIVITY | CELLULAR GENOMICS INC. (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085484-A1 | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity | ERBB4, MAP4K4, EPHB4 | EPHB4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.