Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 15/20 | 0.60 |
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482575 | 0.97 | EPHB4 (0.63) | EPHB4CNR1AURKA | |
| SCHEMBL5489064 | 0.93 | EPHB4 (0.57) | EPHB4CNR1AURKA | |
| SCHEMBL5474303 | 0.92 | EPHB4 (0.67) | EPHB4CNR1AURKA | |
| SCHEMBL5478622 | 0.91 | EPHB4 (0.57) | EPHB4CNR1 | |
| SCHEMBL5474494 | 0.91 | EPHB4 (0.59) | EPHB4CNR1 | |
| SCHEMBL5479596 | 0.91 | EPHB4 (0.61) | EPHB4CNR1AURKA | |
| SCHEMBL5482364 | 0.89 | CNR1 (0.60) | EPHB4CNR1AURKA | |
| SCHEMBL5482760 | 0.89 | EPHB4 (0.70) | EPHB4CNR1AURKA | |
| SCHEMBL5482252 | 0.87 | EPHB4 (0.59) | EPHB4AURKA | |
| SCHEMBL5475345 | 0.86 | EPHB4 (0.69) | EPHB4CNR1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312341-B2 | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. (US) | 2007-12-25 | — | — | US | claimed |