Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | MUSK | O15146 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489740 | 0.86 | AURKA (0.65) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3490681 | 0.84 | AURKA (0.71) | AURKAAURKBKDR | |
| SCHEMBL5491808 | 0.84 | AURKA (0.67) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3490155 | 0.84 | AURKA (0.70) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3489817 | 0.83 | AURKA (0.65) | AURKAAURKBKDR | |
| SCHEMBL3490470 | 0.82 | AURKA (0.63) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3490939 | 0.82 | AURKA (0.63) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3490477 | 0.81 | AURKA (0.67) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL5491101 | 0.80 | AURKA (0.69) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3488760 | 0.79 | AURKA (0.69) | AURKAAURKBKDRPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578755-B1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1578755-A1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | AstraZeneca AB (SE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058781-A1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |