Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.68 |
| ▸ | CPN1 | P15169 | 3/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL743195 | 0.98 | F2 (0.73) | F2CPN1CPB2ALDH1A1L3MBTL1 | |
| SCHEMBL2878726 | 0.84 | — | — | |
| Iodomethane SCHEMBL11097908 | 0.82 | F2 (0.79) | F2CPN1CPB2ALDH1A1L3MBTL1 | |
| SCHEMBL821192 | 0.82 | F2 (1.00) | F2ALDH1A1MAPK1HPGD | |
| SCHEMBL1228214 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL3192296 | 0.82 | — | — | |
| SCHEMBL8281615 | 0.82 | F2 (1.00) | F2ALDH1A1MAPK1HPGD | |
| Iodide SCHEMBL2037191 | 0.82 | — | — | |
| SCHEMBL11288384 | 0.82 | F2 (1.00) | F2ALDH1A1MAPK1HPGD | |
| SCHEMBL11295735 | 0.82 | F2 (1.00) | F2ALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070071702-A1 | Use of a polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | PHILIPPE MICHEL | 2007-03-29 | — | — | US | claimed |
| EP-1302194-B1 | Use of a polyguanidine compound for treating or styling hair, especially for straightening or permanent waving | OREAL (FR) | 2006-07-05 | — | — | EP | claimed |
| US-20040265262-A1 | Compound derived from polyguanidine and use of such a compound for protection and/or care of keratinous fibres | L'OREAL (FR) | 2004-12-30 | — | — | US | claimed |
| US-20030133898-A1 | Use of polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | L'OREAL (FR) | 2003-07-17 | — | — | US | claimed |
| US-20070071702-A1 | Use of a polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | PHILIPPE MICHEL | 2007-03-29 | — | — | US | disclosed |
| US-7144572-B2 | Use of polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | L'OREAL (FR) | 2006-12-05 | — | — | US | disclosed |
| US-20040265262-A1 | Compound derived from polyguanidine and use of such a compound for protection and/or care of keratinous fibres | L'OREAL (FR) | 2004-12-30 | — | — | US | disclosed |
| US-20030133898-A1 | Use of polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | L'OREAL (FR) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040265262-A1 | Compound derived from polyguanidine and use of such a compound for protection and/or care of keratinous fibres | KRT18, XRCC5, XRCC6 | F2 4477/4885CPN1 4636/4885CPB2 4275/4885 |
| US-20070071702-A1 | Use of a polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | KRT18, PTMA, PARG | F2 3011/4885CPN1 4531/4885CPB2 4280/4885 |
| US-20030133898-A1 | Use of polyguanidine compound for treating or shaping the hair, especially for straightening or permanent-waving it | KRT18, PTMA, PARG | F2 2746/4885CPN1 4569/4885CPB2 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.