Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.68 |
| ▸ | EGFR | P00533 | 8/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.68 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | FECH | P22830 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485841 | 0.86 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4487725 | 0.86 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4469496 | 0.85 | ERBB2 (0.73) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5566582 | 0.84 | ERBB2 (0.82) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5566561 | 0.84 | ERBB2 (0.82) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4474476 | 0.84 | ERBB2 (0.75) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4469124 | 0.84 | ERBB2 (0.75) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4478475 | 0.84 | ERBB2 (0.72) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4469221 | 0.83 | ERBB2 (0.71) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL5637744 | 0.83 | ERBB2 (0.87) | ERBB2EGFRKCNH2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511491-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | disclosed |