Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.63 |
| ▸ | EGFR | P00533 | 9/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5699162 | 0.85 | ERBB2 (0.70) | ERBB2EGFRKCNH2 | |
| SCHEMBL4481487 | 0.85 | ERBB2 (0.85) | ERBB2EGFRKCNH2 | |
| SCHEMBL4479915 | 0.82 | ERBB2 (0.65) | ERBB2EGFRKCNH2 | |
| SCHEMBL4485031 | 0.81 | ERBB2 (0.62) | ERBB2EGFRKCNH2 | |
| SCHEMBL4481271 | 0.80 | ERBB2 (0.65) | ERBB2EGFRKCNH2 | |
| SCHEMBL4474648 | 0.80 | ERBB2 (0.87) | ERBB2EGFRKCNH2 | |
| SCHEMBL4469132 | 0.79 | ERBB2 (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL4473766 | 0.79 | ERBB2 (0.75) | ERBB2EGFRKCNH2 | |
| SCHEMBL4476676 | 0.79 | ERBB2 (0.77) | ERBB2EGFRKCNH2 | |
| SCHEMBL4466446 | 0.78 | ERBB2 (0.70) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511491-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | disclosed |