Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394579 | 0.88 | MEN1 (0.54) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL6348868 | 0.84 | HSP90AA1 (0.52) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL398342 | 0.84 | PTPRC (0.50) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL2246184 | 0.81 | PTPRC (0.50) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL5491197 | 0.81 | MEN1 (0.49) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL18339371 | 0.80 | HSP90AA1 (0.49) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL6616312 | 0.80 | HSP90AA1 (0.49) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL18340274 | 0.80 | HSP90AA1 (0.49) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL6338945 | 0.76 | MEN1 (0.47) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL6338942 | 0.76 | MEN1 (0.47) | KMT2AMAPTMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |