SCHEMBL5486891

SCHEMBL5486891

CCOc1cc(CN(c2nc3cc(S(N)(=O)=O)ccc3o2)C2CCNCC2)c(Cl)c(OCC)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SSTR5 P35346 8/20 0.42
HRH1 P35367 4/20 0.40
SSTR1 P30872 2/20 0.40
KCNH2 Q12809 2/20 0.39
SLC6A2 P23975 2/20 0.37
SLC6A4 P31645 2/20 0.37
SLC6A3 Q01959 1/20 0.37
CTSL P07711 1/20 0.35
CTSB P07858 1/20 0.35
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
GAA P10253 1/20 0.34
HPGD P15428 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5479567 0.91 SSTR5 (0.40) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5486961 0.88 SSTR5 (0.42) SSTR5HRH1SLC6A2SLC6A4SLC6A3
SCHEMBL5480915 0.86 SSTR5 (0.42) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5489347 0.86 SSTR5 (0.42) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5493265 0.84 SSTR5 (0.56) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5482380 0.83 SSTR5 (0.50) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL1381121 0.83 SSTR5 (0.54) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5486784 0.83 SSTR5 (0.40) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5486940 0.83 MAPT (0.41) SSTR5HRH1SSTR1KCNH2SLC6A2
SCHEMBL5489076 0.83 SSTR5 (0.46) SSTR5HRH1SSTR1KCNH2SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1858901-A1 BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2007-11-28 EP disclosed
WO-2006094682-A1 BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2006-09-14 WO disclosed