SCHEMBL5487286

SCHEMBL5487286

C[n+]1ccc(C#N)cc1.c1ccc(C([N-]C(c2ccccc2)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 4/20 0.60
TSHR P16473 1/20 0.42
KIF11 P52732 4/20 0.39
SLC22A2 O15244 1/20 0.38
SLC22A1 O15245 1/20 0.38
SLC22A3 O75751 1/20 0.38
SLC6A4 P31645 1/20 0.38
CHAT P28329 3/20 0.35
MAOA P21397 2/20 0.34
MAOB P27338 2/20 0.34
CYP2A6 P11509 2/20 0.32
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5496728 0.83 HDAC8 (0.67) HDAC8TSHRKIF11
SCHEMBL5490294 0.83 TSHR (0.38) HDAC8TSHRKIF11MAOAMAOB
SCHEMBL5490674 0.79 RAD52 (0.38) HDAC8TSHRSLC6A4CYP2A6
SCHEMBL5455838 0.78
SCHEMBL5486758 0.77 RAD52 (0.46) TSHRSLC6A4
SCHEMBL5498495 0.77 RAD52 (0.46) TSHRSLC6A4
SCHEMBL5490872 0.77 RAD52 (0.46) TSHRSLC6A4
SCHEMBL5495945 0.77 RAD52 (0.46) TSHRSLC6A4
SCHEMBL5490090 0.76 TSHR (0.35) HDAC8TSHRKIF11MAOAMAOB
SCHEMBL5495942 0.75 HDAC8 (0.68) HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1854786-A1 Ionic liquids and their use in extraction processes BP p.l.c. (GB) 2007-11-14 EP claimed
EP-1854786-A1 Ionic liquids and their use in extraction processes BP p.l.c. (GB) 2007-11-14 EP disclosed