Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054048 | 0.81 | CHEK1 (0.62) | CHEK1CDK7 | |
| SCHEMBL5054012 | 0.76 | CHEK1 (0.69) | CHEK1CDK7 | |
| SCHEMBL144041 | 0.74 | CHEK1 (0.68) | CHEK1CDK7 | |
| SCHEMBL4156767 | 0.73 | CHEK1 (0.58) | CHEK1CDK7 | |
| SCHEMBL4159485 | 0.73 | CHEK1 (0.77) | CHEK1CDK7 | |
| SCHEMBL5055589 | 0.72 | CHEK1 (0.64) | CHEK1CDK7 | |
| SCHEMBL5054083 | 0.72 | CHEK1 (0.57) | CHEK1CDK7 | |
| SCHEMBL4125079 | 0.63 | ITK (0.68) | CHEK1CDK7 | |
| SCHEMBL5061267 | 0.62 | CHEK1 (0.78) | CHEK1CDK7 | |
| SCHEMBL5058797 | 0.62 | CHEK1 (0.76) | CHEK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851203-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086255-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2006-08-17 | — | — | WO | disclosed |