⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542246 | 1.00 | — | — | |
| SCHEMBL548844 | 1.00 | — | — | |
| SCHEMBL13978920 | 0.76 | — | — | |
| SCHEMBL8322115 | 0.76 | — | — | |
| SCHEMBL2153981 | 0.75 | — | — | |
| SCHEMBL2614303 | 0.75 | TP53 (0.32) | — | |
| SCHEMBL675611 | 0.75 | — | — | |
| SCHEMBL790603 | 0.75 | — | — | |
| SCHEMBL4584154 | 0.75 | TP53 (0.32) | — | |
| SCHEMBL12808547 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118652259-A | New total synthesis method of ixabepilone (Ixabepilone) and derivatives thereof | 南方科技大学 | 2024-09-17 | — | — | CN | disclosed |
| US-12024529-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-12024529-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-12024529-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-20230271981-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230271981-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230271981-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-08-31 | — | — | US | disclosed |
| US-11685747-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685747-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685747-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20040053995-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2004-03-18 | — | — | US | disclosed |
| WO-2004018478-A2 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2004-03-04 | — | — | WO | disclosed |
| US-20030134883-A1 | 14-Methyl-epothilones | KOSAN BIOSCIENCES,INC. | 2003-07-17 | — | — | US | disclosed |
| US-6589968-B2 | Anticancer, antiproliferative and antiarthritic agents | KOSAN BIOSCIENCES, INC. | 2003-07-08 | — | — | US | disclosed |
| WO-2003045324-A2 | 14-METHYL-EPOTHILONES | KOSAN BIOSCIENCES, INC. (US) | 2003-06-05 | — | — | WO | disclosed |
| US-20030045711-A1 | Epothilone derivatives and methods for making and using the same | KOSAN BIOSCIENCES, INC. | 2003-03-06 | — | — | US | disclosed |
| US-20020193361-A1 | Epothilone derivatives and methods for making and using the same | KOSAN BIOSCIENCES, INC. | 2002-12-19 | — | — | US | disclosed |
| US-6489314-B1 | DUE TO THE INCREASING INTEREST IN EPOTHILONES AS ANTI-CANCER AGENTS, NOVEL DERIVATIVES OF THESE COMPOUNDS ARE NEEDED AND DESIRED TO MORE FULLY DEVELOP THEIR THERAPEUTIC POTENTIAL | KOSAN BIOSCIENCES, INC. | 2002-12-03 | — | — | US | disclosed |
| US-20020156110-A1 | Epothilone compounds and methods for making and using the same | KOSAN BIOSCIENCES, INC. | 2002-10-24 | — | — | US | disclosed |
| WO-2002080846-A2 | EPOTHILONE DERIVATIVES AND METHODS FOR MAKING AND USING THE SAME | KOSAN BIOSCIENCES, INC. (US) | 2002-10-17 | — | — | WO | disclosed |