Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 18/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | HCK | P08631 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | MST1R | Q04912 | 2/20 | 0.57 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.57 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.57 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | RAB6A | P20340 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488818 | 0.92 | AURKA (0.66) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL5489095 | 0.89 | AURKA (0.60) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3488785 | 0.86 | AURKA (0.64) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3489335 | 0.85 | AURKA (0.73) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL5489066 | 0.84 | AURKA (0.65) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL5490282 | 0.84 | AURKA (0.70) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL5492290 | 0.84 | AURKA (0.65) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3488369 | 0.84 | AURKA (0.71) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3489765 | 0.83 | AURKA (0.71) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3489328 | 0.83 | AURKA (0.80) | AURKAAURKBRIPK2EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578755-B1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2007-08-22 | — | — | EP | disclosed |