Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.69 |
| ▸ | KDR | P35968 | 11/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.69 |
| ▸ | JAK3 | P52333 | 9/20 | 0.69 |
| ▸ | TEK | Q02763 | 4/20 | 0.69 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493977 | 0.91 | LCK (0.77) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5489229 | 0.84 | LCK (0.65) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5500876 | 0.83 | LCK (0.85) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5489108 | 0.83 | LCK (0.82) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5490529 | 0.82 | LCK (0.70) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5499000 | 0.82 | LCK (1.00) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5498732 | 0.81 | LCK (0.74) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5501211 | 0.81 | LCK (0.74) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5499042 | 0.81 | LCK (0.74) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5501072 | 0.81 | LCK (0.74) | LCKKDRMAPK14JAK3TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |