Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.63 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305182 | 0.89 | EGFR (0.80) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL6980188 | 0.87 | ERBB2 (0.73) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL215281 | 0.86 | EGFR (0.69) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL30638102 | 0.86 | EGFR (0.69) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL2255348 | 0.86 | EGFR (0.69) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL4864889 | 0.82 | ERBB2 (0.67) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL2247576 | 0.82 | EGFR (0.64) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL29087930 | 0.82 | EGFR (0.71) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL3808064 | 0.82 | ERBB2 (0.83) | EGFRERBB2KCNH2 | |
| SCHEMBL217990 | 0.82 | EGFR (0.68) | EGFRERBB2LCKGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844022-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071017-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |