Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14508206 | 0.84 | ELANE (0.39) | ALDH1A1ELANELMNAMAPTTP53 | |
| SCHEMBL14508173 | 0.82 | ELANE (0.40) | ALDH1A1ELANELMNAMAPTKMT2A | |
| SCHEMBL14608770 | 0.78 | KMT2A (0.38) | ALDH1A1ELANELMNAPOLBKMT2A | |
| SCHEMBL14608741 | 0.73 | HTT (0.41) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL12384123 | 0.72 | PIK3CG (0.56) | ELANELMNAMAPTTP53POLB | |
| SCHEMBL1748063 | 0.71 | KDM4E (0.56) | ALDH1A1ELANEMAPTTP53KMT2A | |
| SCHEMBL4704291 | 0.70 | MAPT (0.56) | ALDH1A1LMNAMAPTKMT2AHTT | |
| SCHEMBL3573726 | 0.70 | HTT (0.50) | ALDH1A1LMNAPOLBKMT2AHTT | |
| SCHEMBL14985575 | 0.70 | HTT (0.50) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL1563928 | 0.69 | ESR1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |