Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.72 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | MUSK | O15146 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490775 | 0.88 | AURKA (0.81) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL5489198 | 0.87 | AURKA (0.73) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL5488620 | 0.87 | AURKA (0.74) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL4299782 | 0.87 | AURKA (0.80) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL3488623 | 0.86 | AURKA (0.71) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3489727 | 0.86 | AURKA (0.67) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3489844 | 0.86 | AURKA (0.82) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL4293822 | 0.85 | AURKA (0.83) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL5485776 | 0.85 | AURKA (0.78) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL6525973 | 0.85 | AURKA (0.84) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847539-A1 | Quinazoline derivatives | AstraZeneca AB (SE) | 2007-10-24 | — | — | EP | disclosed |