Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255908 | 0.92 | KDM4E (0.71) | KDM4EMAPTHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL1658107 | 0.92 | KDM4E (0.71) | KDM4EMAPTHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL1658092 | 0.85 | KDM4E (0.73) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 | |
| SCHEMBL1658091 | 0.85 | KDM4E (0.73) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 | |
| SCHEMBL4171862 | 0.85 | KDM4E (0.77) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 | |
| SCHEMBL4171864 | 0.85 | KDM4E (0.77) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 | |
| SCHEMBL4260313 | 0.85 | KDM4E (0.77) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 | |
| SCHEMBL5239415 | 0.78 | KDM4E (1.00) | KDM4EMAPTHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL6244260 | 0.78 | KDM4E (0.67) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 | |
| SCHEMBL6347706 | 0.78 | KDM4E (0.67) | KDM4EMAPTHSD17B10ALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824498-A2 | METHODS AND COMPOSITIONS FOR TREATING CELLULAR PROLIFERATIVE DISEASES | THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006053315-A2 | METHODS AND COMPOSITIONS FOR TREATING CELLULAR PROLIFERATIVE DISEASES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-05-18 | — | — | WO | disclosed |