Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 20/20 | 0.70 |
| ▸ | HRH1 | P35367 | 9/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.70 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.68 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585578 | 0.91 | SSTR5 (0.84) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3569614 | 0.90 | SSTR5 (0.85) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3573097 | 0.90 | SSTR5 (0.84) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3578522 | 0.84 | SSTR5 (0.92) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL4951995 | 0.84 | SSTR5 (0.80) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3577798 | 0.83 | SSTR5 (0.85) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3573859 | 0.83 | SSTR5 (0.82) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3576952 | 0.83 | SSTR5 (0.84) | SSTR5HRH1KCNH2SSTR1HTR2B | |
| SCHEMBL3584151 | 0.83 | SSTR5 (0.85) | SSTR5HRH1KCNH2SSTR1 | |
| SCHEMBL3569737 | 0.83 | SSTR5 (0.84) | SSTR5HRH1KCNH2SSTR1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |