Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.57 |
| ▸ | KDR | P35968 | 18/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 14/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5490424 | 0.88 | LCK (0.66) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5498357 | 0.88 | LCK (0.67) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5490401 | 0.83 | LCK (0.72) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5492984 | 0.83 | LCK (0.66) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5502215 | 0.82 | LCK (0.64) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5493108 | 0.82 | LCK (0.68) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5497303 | 0.81 | LCK (0.78) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5497877 | 0.81 | LCK (0.78) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5491984 | 0.81 | LCK (0.62) | LCKKDRMAPK14JAK3SRC | |
| SCHEMBL5491593 | 0.81 | LCK (0.67) | LCKKDRMAPK14JAK3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |