Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | LCK | P06239 | 10/20 | 0.43 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494873 | 0.75 | MAPK14 (0.44) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL5494001 | 0.74 | LCK (0.63) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL21416755 | 0.74 | MAPK14 (0.50) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL5501111 | 0.73 | LCK (0.60) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL5497131 | 0.73 | ABL1 (0.58) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL5494440 | 0.73 | MAPK14 (0.63) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL5500272 | 0.71 | LCK (0.45) | KDRLCKMAPK14ABL1MAP4K4 | |
| SCHEMBL5490425 | 0.71 | LCK (0.45) | KDRLCKMAPK14ALOX5APABL1 | |
| SCHEMBL5504803 | 0.70 | MAPK14 (0.55) | KDRLCKJAK3MAPK14TEK | |
| SCHEMBL5490697 | 0.69 | ABL1 (0.64) | KDRLCKJAK3MAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |