Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 15/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | HCK | P08631 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MST1R | Q04912 | 2/20 | 0.45 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.45 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.45 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27741270 | 0.99 | FGFR2 (0.49) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL27646698 | 0.97 | FGFR2 (0.49) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL1343718 | 0.82 | FGFR2 (0.54) | FGFR2AURKAAURKBKDRRIPK2 | |
| Hydrochloric Acid SCHEMBL1345950 | 0.81 | FGFR2 (0.54) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL3489095 | 0.79 | FGFR2 (0.54) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL27985515 | 0.77 | AURKA (0.56) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL27694403 | 0.77 | EGFR (0.40) | FGFR2KDREGFRKITPDGFRA | |
| SCHEMBL27761821 | 0.74 | FGFR2 (0.46) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL1345634 | 0.73 | AURKA (0.77) | FGFR2AURKAAURKBKDRRIPK2 | |
| SCHEMBL3490355 | 0.73 | AURKA (0.77) | FGFR2AURKAAURKBKDRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101443339-B | Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group | ASTRAZENECA AB | 2012-07-04 | — | — | CN | disclosed |
| CN-101074227-B | Phosphine acyloxy quinazoline derivatives and their medicine uses | ASTRAZENECA AB | 2010-09-29 | — | — | CN | disclosed |
| CN-100349906-C | Phosphonoxyquinazoline derivatives and pharmaceutical use thereof | ASTRAZENECA AB (SE) | 2007-11-21 | — | — | CN | disclosed |
| CN-101074227-A | Phosphine acyloxy quinazoline derivatives and their medicine using | ASTRAZENECA AB (SE) | 2007-11-21 | — | — | CN | disclosed |
| EP-1847539-A1 | Quinazoline derivatives | AstraZeneca AB (SE) | 2007-10-24 | — | — | EP | disclosed |
| CN-1764668-A | Phosphonoxyquinazoline derivatives and pharmaceutical use thereof | ASTRAZENECA AB (SE) | 2006-04-26 | — | — | CN | disclosed |