Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 6/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496069 | 0.88 | SRC (0.68) | SRCFYNAURKACCNCCDKN1A | |
| SCHEMBL2248251 | 0.85 | FYN (0.58) | SRCFYNEGFRMAPK1LMNA | |
| SCHEMBL5499111 | 0.84 | SRC (0.71) | SRCFYNAURKACCNCCDKN1A | |
| SCHEMBL5496213 | 0.84 | FYN (0.80) | SRCFYNAURKACCNCCDKN1A | |
| SCHEMBL2249929 | 0.83 | EGFR (0.51) | EGFRLMNADYRK1A | |
| SCHEMBL2251058 | 0.82 | AURKB (0.53) | SRCFYNAURKAEGFRLMNA | |
| SCHEMBL2248227 | 0.79 | ERBB2 (0.60) | EGFRMAPK1LMNACYP1A2CYP3A4 | |
| SCHEMBL5494040 | 0.78 | EGFR (0.44) | SRCFYNEGFRMAPK1LMNA | |
| SCHEMBL2248288 | 0.77 | EGFR (0.65) | EGFR | |
| SCHEMBL2250352 | 0.75 | EGFR (0.72) | SRCEGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844022-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071017-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |