Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551560 | 1.00 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL549414 | 1.00 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL2698090 | 1.00 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL551561 | 1.00 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL2698085 | 1.00 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL551021 | 0.98 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL2700110 | 0.98 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL2700111 | 0.98 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL551022 | 0.98 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A | |
| SCHEMBL549383 | 0.98 | CRBN (0.46) | CRBNPTPN2PTPN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |